Significance of 5-S-Cysteinyldopa as a Marker for Melanoma

K Wakamatsu, S Fukushima, A Minagawa… - International Journal of …, 2020 - mdpi.com
… melanoma cell lines and related to the 5SCD levels, pigment and … (PB-DOPA) is formed when
hydroxyl radicals react with … , such as UV exposure, pigmentation may also proceed by the …

Metabolic basis and clinical evidence for skin lightening effects of thiol compounds

YC Boo - Antioxidants, 2022 - mdpi.com
… or decrease can cause serious pigmentation disorders. The melanin pigment of the skin
is … 6-S-Glutathionyl dopa is also formed at a lower yield (5%) compared to 5-S-glutathionyl …

Chemical and biochemical control of skin pigmentation with special emphasis on mixed melanogenesis

K Wakamatsu, JH Zippin, S Ito - Pigment cell & melanoma …, 2021 - Wiley Online Library
… (ortho-quinone of L-DOPA, DQ) which is formed via the oxidation of l-… 5-S-cysteinyldopa
(5SCD) is rapidly formed as the major CD … The low rate of extracellular cystine transport into sut …

[PDF][PDF] PIGMENT CELL & MELANOMA Research

K Wakamatsu, JH Zippin, S Ito - 2021 - academia.edu
… The diversity of pigmentation in vertebrates is mainly … (ortho- quinone of L- DOPA, DQ) which
is formed via the oxidation of l… 5- S- cysteinyldopa (5SCD) is rapidly formed as the major CD …

Photodegradation of eumelanin and pheomelanin and its pathophysiological implications

S Ito, K Wakamatsu, T Sarna - Photochemistry and …, 2018 - Wiley Online Library
… oxidation of 5-S-cysteinyldopa or a 1:1 mixture of DOPA and … of the degree of pigmentation,
the pheomelanin being mostly … cell lines showed that eumelanin is the predominant pigment

Photobleaching of pheomelanin increases its phototoxic potential: Physicochemical studies of synthetic pheomelanin subjected to aerobic photolysis

A Zadlo, G Szewczyk, M Sarna… - Pigment cell & …, 2019 - Wiley Online Library
… from enzymatic oxidation of 5-S-cysteinyldopa, subjected to … greater than that of a synthetic
dopa-melanin (Figure S3). The W-… is the dominant type of pigmentation in Caucasians, the …

Neuromelanin in Parkinson's disease: tyrosine hydroxylase and tyrosinase

T Nagatsu, A Nakashima, H Watanabe, S Ito… - International journal of …, 2022 - mdpi.com
… neurotoxic, causing DA cell death; and black pigments termed … the oxidation of DOPA to
produce 5-S-cysteinyldopa (5SCD) … for cell death of DA neurons depending on the intracellular

Transcriptome analysis of feather follicles reveals candidate genes and pathways associated with pheomelanin pigmentation in chickens

X Zheng, B Zhang, Y Zhang, H Zhong, R Nie, J Li… - Scientific reports, 2020 - nature.com
… ,4-dihydroxyphenylalanine (dopa) and the oxidation of dopa to … Dopaquinone is transformed
into 5-S-cysteinyldopa when … and white plumage formation, we inferred that the five pigment-…

Melanosome biogenesis in the pigmentation of mammalian skin

L Le, J Sirés-Campos, G Raposo… - Integrative and …, 2021 - academic.oup.com
pigment cells of the eye (including retinal pigment epithelial … within membrane-bound
intracellular compartments called … either 2-S- or 5-S-cysteinyldopa, which are both intermediates in …

The role of tyrosine hydroxylase as a key player in neuromelanin synthesis and the association of neuromelanin with Parkinson's disease

T Nagatsu, A Nakashima, H Watanabe, S Ito… - Journal of Neural …, 2023 - Springer
… using neural cell cultures that synthetic DOPA pheomelanin … , on average, the intracellular
pigment optical density in SNpc … Lewy body-like formation, and nigrostriatal neurodegeneration…